If you are suffering from sharp pain during or after bowel movements, you may be dealing with an anal fissure—a small tear in the lining of the back passage. GTN Cream (Glyceryl Trinitrate Rectal Ointment 0.2%) is a clinically proven topical treatment that helps relax the internal anal sphincter, increase blood flow to the affected area, and promote natural healing of chronic fissures.

How Does GTN Cream Work?

GTN Cream works by releasing nitric oxide, which relaxes the smooth muscle of the anal canal. This reduces spasms, lowers resting pressure, and allows small tears in the skin to heal. Unlike harsh laxatives or temporary painkillers, this rectal ointment targets the root cause of fissure pain.

Key benefits include:

Relieves acute and chronic anal pain
Reduces sphincter spasms
Promotes healing within 4–8 weeks
Non-surgical option for fissure management

Clinical Effectiveness of GTN Ointment

In a clinical study involving 93 patients (53 male, median age 42 years), those using 0.2% GTN Ointment twice daily for up to 8 weeks showed significant results:

Parameter	Clinical Outcome
Healing Rate	61% (57 of 93 fissures healed)
Recurrence Rate	25 patients had recurrence after median 6 months
Re-treatment Success	88% healed with a second GTN course
Surgery Needed	Only 4% eventually required sphincterotomy
Headache Side Effect	49% experienced mild headache; 4% discontinued

Benefits of GTN Cream for Anal Fissures

✅ High success rate – Up to 68% healing in chronic cases
✅ Avoids surgery – Only 4% need sphincterotomy after failed GTN use
✅ Easy to apply – Topical application twice daily at 12-hour intervals
✅ Safe for long-term use – Can be used for up to 8 weeks if necessary
✅ Effective for recurrent fissures – 88% heal with second course

How to Use GTN Cream (Glyceryl Trinitrate Rectal Ointment)

Wash your hands and the anal area gently.
Apply a small amount (approx. 1 cm) of GTN Cream to the tip of your finger.
Insert the tip just inside the anal canal and spread the ointment to the anoderm.
Use twice each day – morning and evening – at 12-hour intervals.
Continue for up to 8 weeks as advised by your doctor.
If you experience a headache, start with a smaller amount and gradually increase.

Note: Do not exceed the prescribed dose. Store in a cool place away from direct sunlight.